Norfriedelins A-C with acetylcholinesterase inhibitory activity from acerola tree (Malpighia emarginata).

@article{Liu2013NorfriedelinsAW,
  title={Norfriedelins A-C with acetylcholinesterase inhibitory activity from acerola tree (Malpighia emarginata).},
  author={Jie-Qing Liu and Xingrong Peng and Xu-Yang Li and Ting-zhao Li and Wei-Ming Zhang and Lei Shi and Jiang Han and Minghua Qiu},
  journal={Organic letters},
  year={2013},
  volume={15 7},
  pages={
          1580-3
        }
}
Three novel norfriedelanes, A-C (1-3), were isolated from the branches and roots of Malpighia emarginata . Their structures and absolute configurations were determined by 1D and 2D NMR techniques and X-ray crystallographic analysis. Norfriedelin A (possessing an α-oxo-β-lactone group) and norfriedelin B (with a keto-lactone group) showed acetylcholinesterase inhibitory effects with the IC50 values of 10.3 and 28.7 μM, respectively. 

Monoterpene esters and aporphine alkaloids from Illigera aromatica with inhibitory effects against cholinesterase and NO production in LPS-stimulated RAW264.7 macrophages

The chemical structure and bioactive foundation for using I. aromatica as an herbal medicine is provided and four new monoterpene phenylpropionic acid esters and one new aporphine alkaloid, illigeranine, are identified.

Three New Tetranorditerpenes from Aerial Parts of Acerola Cherry (Malpighia emarginata)

The constituents of aerial parts of acerola are examined, and three new tetranorditerpenes acerolanins A–C with a rare 2H-benz[e]inden-2-one substructure were isolated and studied for their cytotoxic activity.

aytenus distichophylla and Salacia crassifolia : source of products with otential acetylcholinesterase inhibition

The phytochemical study of the extract leaves from Maytenus distichophylla Mart. and Salacia crassifolia (Mart. ex Schult.) G. Don, Celastraceae, resulted in the isolation of 3-oxofriedelane, 3

Oxetane-containing metabolites: origin, structures, and biological activities

The biological activity of OCC that is produced by bacteria and Actinomycetes demonstrates antineoplastic, antiviral, and antifungal activity with confidence an angiogenesis stimulator, respiratory analeptic, and antiallergic activity.

Friedelane triterpenoids: transformations toward A-ring modifications including 2-homoderivatives

Friedelin and its derivatives, commonly known as friedelane triterpenoids, exhibit potential biological effects ranging from antimicrobial to anticancer to anti-HIV. To modify the A-ring of the

Acerola, an untapped functional superfruit: a review on latest frontiers

A comprehensive literature analysis was carried out with reference to the latest frontiers on the compositional characteristics of acerola with emphasis has been given on newer dimensions of functional aspects of ascorbic acid and allied work and pectin andpectin methylesterase.

References

SHOWING 1-10 OF 22 REFERENCES

A new triterpene with antinociceptive activity from Maytenus robusta

3,15-dioxo-21α-hydroxy friedelane was analyzed against the writhing test in mice and exhibited potent dose-dependent effects with an ID50 value of 12.5'± 2.1 µmol kg−1 and a maximal inhibition of 85.90%.

Two epimeric friedelane triterpenes isolated from Maytenus truncata Reiss: 1H and 13C chemical shift assignments

An NMR study of 3α‐ and 3β‐friedelinol is described. In addition to conventional 1D NMR methods, 2D shift‐correlated NMR experiments HMQC [(1J(C,H)], HMBC [nJ(C,H); n=2 and 3] and 2D 1H,1H‐NOESY were

Structures of new secofriedelane and friedelane acids from Calophyllum inophyllum of French Polynesia

Three new friedelane‐type triterpenoids were isolated from the leaves of Calophyllum inophyllUM (Clusiaceae) grown in French Polynesia by the concerted application of 2D NMR techniques including gs‐COSY, gs•HMQC and gs-HMBC.

Friedeland Triterpenoids from Peritassa compta: Complete 1H and 13C Assignments by 2D nmr Spectroscopy

An investigation of the stems and bark of Peritassa compta has led to the isolation of three new natural products, friedelane-3,15-dione [3], 15α-hydroxyfriedelin [4], and

Triterpenoid Ketones from Lingnania chungii MOCLURE : Arborinone, Friedelin and Glutinone

The powder coating of a bamboo, Lingnania chungii MCCLURE (=Bambusa chungii) was found to be a rich source of the 3-oxo pentacyclic triterpenes (25% on the recovery basis by chromatography on silica

Hemisynthetic secofriedelane triterpenes with inhibitory activity against the growth of human tumor cell lines in vitro.

Only compounds 7 and 9 were found to possess significant growth inhibitory effects, exhibiting GI(50) values that range from 24.6 to 32.8 microM and 10.9 to 17.6 microM, respectively.

A New Cytotoxic Friedelane Acid – Pluricostatic Acid – and Other Compounds from the Leaves of Marila pluricostata

Bioassay-guided fractionation of the dichloromethane extract of the leaves of Marila pluricostata led to the isolation of 2α,3β-dihydroxy-D:A-friedoolean-28-oic acid (pluricostatic acid), a new

Endodesmiadiol, a friedelane triterpenoid, and other antiplasmodial compounds from Endodesmia calophylloides.

From the ethyl acetate extract of the stem bark of Endodesmia calophylloides, a novel friedelane triterpenoid named endodesmiadiol has been isolated and the antiplasmodial activity of the isolated compounds was evaluated against the W2 strain of Plasmodium falciparum which is resistant to chloroquine and other antimalarial drugs.