• DOI:10.1111/j.1479-828X.1992.tb01954.x
• Corpus ID: 19741452

Norethisterone and Gestational Diabetes

@article{Beischer1992NorethisteroneAG,
  title={Norethisterone and Gestational Diabetes},
  author={Norman A. Beischer and Timothy Cookson and Mary T. Sheedy and Peter Wein},
  journal={Australian and New Zealand Journal of Obstetrics and Gynaecology},
  year={1992},
  volume={32}
}

• N. Beischer, T. Cookson, +1 author P. Wein
• Published 1 August 1992
• Medicine, Biology
• Australian and New Zealand Journal of Obstetrics and Gynaecology

Summary: In a single practice during the 21 years 1971–1991, the incidence of gestational diabetes in pregnancies in which norethisterone was prescribed was 32.4% (22 of 69) in comparison with 7.1% in pregnancies in which the women did not take norethisterone (137 of 1,684) (p< 0.001). Gestational diabetes was no less severe (degree of hyper‐glycaemia, need for insulin therapy) when associated with norethisterone. However, follow‐up revealed that gestational diabetes when associated with norethisterone had a lesser risk of emerging diabetes mellitus and impaired glucose tolerance. Mascu‐linization of a female fetus occurred in 5 of 39 (12.8%) exposed to norethisterone; all were cases of clitoral hypertrophy not requiring surgical treatment. Norethisterone in these 69 pregnanices accounted for 33.3% (5 of 15) cases of clitoral hypertrophy diagnosed in 100,756 consecutive1 births.