Norepinephrine transporters have channel modes of conduction.

  title={Norepinephrine transporters have channel modes of conduction.},
  author={Aurelio Galli and Randy D. Blakely and Louis J. DeFelice},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={93 16},
Neurotransmitter transporters couple to existing ion gradients to achieve reuptake of transmitter into presynaptic terminals. For coupled cotransport, substrates and ions cross the membrane in fixed stoichiometry. This is in contrast to ion channels, which carry an arbitrary number of ions depending on the channel open time. Members of the gamma-aminobutyric acid transporter gene family presumably function with fixed stoichiometry in which a set number of ions cotransport with one transmitter… CONTINUE READING


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Psychopharmacology: The Fourth Generation ofProgress

  • E. Barker, R. D. Blakely
  • New York),
  • 1995

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