Norepinephrine stimulates behavioral activation in rats following depletion of nucleus accumbens dopamine.

@article{Swerdlow1989NorepinephrineSB,
  title={Norepinephrine stimulates behavioral activation in rats following depletion of nucleus accumbens dopamine.},
  author={Neal R. Swerdlow and George F. Koob},
  journal={Pharmacology, biochemistry, and behavior},
  year={1989},
  volume={33 3},
  pages={595-9}
}
Intraventricular (ICV) infusion of norepinephrine (NE) produces locomotor activation in rats that is greatly potentiated by prior depletion of whole brain catecholamines by ICV injection of 6-hydroxydopamine (6OHDA). In a series of experiments, the neural substrates of this potentiated locomotor response were examined. One group of animals received ICV infusion of 6OHDA to deplete whole brain catecholamines. Other rats were pretreated with desmethylimipramine (DMI) and then received 6OHDA… CONTINUE READING