Norepinephrine reverses the effects of activin A on DNA synthesis and apoptosis in cultured rat hepatocytes.

@article{Zhang1996NorepinephrineRT,
  title={Norepinephrine reverses the effects of activin A on DNA synthesis and apoptosis in cultured rat hepatocytes.},
  author={Y Q Zhang and Masanori Kanzaki and Hirosato Mashima and Tetsuya Mine and Itaru Kojima},
  journal={Hepatology},
  year={1996},
  volume={23 2},
  pages={288-93}
}
Activin A, an autocrine factor produced by hepatocytes, inhibits mitogen-stimulated DNA synthesis and induces apoptotic death of cultured rat hepatocytes. Several lines of evidence indicate that norepinephrine (NE), as a comitogenic growth factor, alters the balance between growth stimulation and inhibition and acts as a trigger for the initiation of hepatocyte proliferation. In the present study, we examined whether NE modulated the effects of activin A on rat hepatocytes in primary culture… CONTINUE READING
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