Norepinephrine represses the expression of toxA and the siderophore genes in Pseudomonas aeruginosa.

@article{Li2009NorepinephrineRT,
  title={Norepinephrine represses the expression of toxA and the siderophore genes in Pseudomonas aeruginosa.},
  author={Wang Li and Mark Lyte and Primrose P E Freestone and Aziba Ajmal and Jane A. Colmer-Hamood and Abdul N Hamood},
  journal={FEMS microbiology letters},
  year={2009},
  volume={299 1},
  pages={100-9}
}
Among the different extracellular virulence factors produced by Pseudomonas aeruginosa are exotoxin A (ETA) and the pyoverdine and pyochelin siderophores. Production of ETA and the siderophores requires the function of the iron-starvation sigma factor PvdS, the transcriptional activator RegA, and the AraC-activator PchR. Iron represses the production of ETA and the siderophores by repressing the expression of pvdS, regA, and pchR. PvdS regulates the expression of the ETA gene, toxA, regA, and… CONTINUE READING

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