Norepinephrine protects cortical neurons against microglial-induced cell death.

  title={Norepinephrine protects cortical neurons against microglial-induced cell death.},
  author={Jos{\'e} Luis Mu{\~n}oz Madrigal and Douglas L Feinstein and Cinzia Dello Russo},
  journal={Journal of neuroscience research},
  volume={81 3},
Interleukin-1 beta (IL-1beta) is one of the main cytokines involved in the inflammatory response; it has multiple effects that can contribute to cell damage, one of which is the upregulation of the inducible form of nitric oxide (NO) synthase (NOS2) in certain cell types. We demonstrated previously that in vivo, cortical microglial inflammatory responses were increased when noradrenaline (NE) levels were depleted, suggesting that NE can reduce microglial activation. In the present report, we… CONTINUE READING
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