Norepinephrine-induced sustained inward current in brown fat cells: alpha(1)-mediated by nonselective cation channels.

@article{Koivisto2000NorepinephrineinducedSI,
  title={Norepinephrine-induced sustained inward current in brown fat cells: alpha(1)-mediated by nonselective cation channels.},
  author={Ari Koivisto and Detlef Siemen and Jan Nedergaard},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2000},
  volume={279 5},
  pages={E963-77}
}
The nature of the sustained norepinephrine-induced depolarization in brown fat cells was examined by patch-clamp techniques. Norepinephrine (NE) stimulation led to a whole cell current response consisting of two phases: a first inward current, lasting for only 1 min, and a sustained inward current, lasting as long as the adrenergic stimulation was maintained. The nature of the sustained current was here investigated. It could be induced by the alpha(1)-agonist cirazoline but not by the beta(3… CONTINUE READING

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