Norepinephrine-evoked calcium transients in cultured cerebral type 1 astroglia.

@article{Salm1990NorepinephrineevokedCT,
  title={Norepinephrine-evoked calcium transients in cultured cerebral type 1 astroglia.},
  author={Adrienne K. Salm and Ken D. McCarthy},
  journal={Glia},
  year={1990},
  volume={3 6},
  pages={529-38}
}
We have used the CA++ indicator dye fura-2 AM and computerized imaging systems to investigate adrenergic regulation of intracellular calcium in cultured cerebral type 1 astroglia. We have found that norepinephrine (NE) and other adrenergic agonists stimulate increases in intracellular calcium in over 80% of type 1 astroglia tested. A wide range in effective NE concentrations was seen. With sufficient agonist concentrations the calcium response was biphasic, exhibiting an initial sharp peak… CONTINUE READING

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