Norepinephrine decreases synaptic inhibition in the rat hippocampus.

  title={Norepinephrine decreases synaptic inhibition in the rat hippocampus.},
  author={Daniel V. Madison and Roger A Nicoll},
  journal={Brain research},
  volume={442 1},
The effects of norepinephrine (NE) on inhibitory synaptic potentials were studied on CA1 pyramidal neurons in the hippocampal slice in vitro. Norepinephrine caused the appearance of multiple population spikes in the CA1 region of the hippocampal slice, reminiscent of the actions of gamma-aminobutyric acid (GABA) antagonists. Intracellular recording revealed that NE causes a marked and reversible reduction in inhibitory postsynaptic potentials (IPSPs) recorded in CA1 pyramidal cells. This… CONTINUE READING
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