Norepinephrine and Neural Plasticity: The Effects of Xylamine on Experience-Induced Changes in Brain Weight, Memory, and Behavior

@article{Benloucif1995NorepinephrineAN,
  title={Norepinephrine and Neural Plasticity: The Effects of Xylamine on Experience-Induced Changes in Brain Weight, Memory, and Behavior},
  author={S Benloucif and Edward L. Bennett and Mark R. Rosenzweig},
  journal={Neurobiology of Learning and Memory},
  year={1995},
  volume={63},
  pages={33-42}
}
The hypothesis that norepinephrine (NE) is critically involved in neural plasticity was tested by administering xylamine, (N-2-chloroethyl-2-methylbenzylamine, 50 mg/kg ip) a noradrenergic neurotoxin, to young rats prior to maze training or environmentally enriched housing. In saline-treated rats, exposure to enriched conditions significantly increased the weight of occipital, dorsal, and ventral cortices and the remaining brain compared to individually housed rats. In xylamine-treated rats… CONTINUE READING

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