Nordihydroguaiaretic acid inhibits an activated fibroblast growth factor receptor 3 mutant and blocks downstream signaling in multiple myeloma cells.

@article{Meyer2008NordihydroguaiareticAI,
  title={Nordihydroguaiaretic acid inhibits an activated fibroblast growth factor receptor 3 mutant and blocks downstream signaling in multiple myeloma cells.},
  author={April N. Meyer and Christopher W. McAndrew and Daniel J. Donoghue},
  journal={Cancer research},
  year={2008},
  volume={68 18},
  pages={7362-70}
}
Activating mutations within fibroblast growth factor receptor 3 (FGFR3), a receptor tyrosine kinase, are responsible for human skeletal dysplasias including achondroplasia and the neonatal lethal syndromes, Thanatophoric Dysplasia (TD) type I and II. Several of these same FGFR3 mutations have also been identified somatically in human cancers, including multiple myeloma, bladder carcinoma, and cervical cancer. Based on reports that strongly activated mutants of FGFR3 such as the TDII (K650E… CONTINUE READING

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Several of these same FGFR3 mutations have also been identified somatically in human cancers , including multiple myeloma , bladder carcinoma , and cervical cancer .
Several of these same FGFR3 mutations have also been identified somatically in human cancers , including multiple myeloma , bladder carcinoma , and cervical cancer .
Several of these same FGFR3 mutations have also been identified somatically in human cancers , including multiple myeloma , bladder carcinoma , and cervical cancer .
Several of these same FGFR3 mutations have also been identified somatically in human cancers , including multiple myeloma , bladder carcinoma , and cervical cancer .
Several of these same FGFR3 mutations have also been identified somatically in human cancers , including multiple myeloma , bladder carcinoma , and cervical cancer .
Nordihydroguaiaretic acid inhibits an activated fibroblast growth factor receptor 3 mutant and blocks downstream signaling in multiple myeloma cells . Activating mutations within fibroblast growth factor receptor 3 ( FGFR3 ) , a receptor tyrosine kinase , are responsible for human skeletal dysplasias including achondroplasia and the neonatal lethal syndromes , Thanatophoric Dysplasia ( TD ) type I and II .
Nordihydroguaiaretic acid inhibits an activated fibroblast growth factor receptor 3 mutant and blocks downstream signaling in multiple myeloma cells . Activating mutations within fibroblast growth factor receptor 3 ( FGFR3 ) , a receptor tyrosine kinase , are responsible for human skeletal dysplasias including achondroplasia and the neonatal lethal syndromes , Thanatophoric Dysplasia ( TD ) type I and II .
Nordihydroguaiaretic acid inhibits an activated fibroblast growth factor receptor 3 mutant and blocks downstream signaling in multiple myeloma cells . Activating mutations within fibroblast growth factor receptor 3 ( FGFR3 ) , a receptor tyrosine kinase , are responsible for human skeletal dysplasias including achondroplasia and the neonatal lethal syndromes , Thanatophoric Dysplasia ( TD ) type I and II .
Several of these same FGFR3 mutations have also been identified somatically in human cancers , including multiple myeloma , bladder carcinoma , and cervical cancer .
Nordihydroguaiaretic acid inhibits an activated fibroblast growth factor receptor 3 mutant and blocks downstream signaling in multiple myeloma cells . Activating mutations within fibroblast growth factor receptor 3 ( FGFR3 ) , a receptor tyrosine kinase , are responsible for human skeletal dysplasias including achondroplasia and the neonatal lethal syndromes , Thanatophoric Dysplasia ( TD ) type I and II .
Several of these same FGFR3 mutations have also been identified somatically in human cancers , including multiple myeloma , bladder carcinoma , and cervical cancer .
FGFR3 geneGene associated with diseaseAchondroplasia
Nordihydroguaiaretic acid inhibits an activated fibroblast growth factor receptor 3 mutant and blocks downstream signaling in multiple myeloma cells . Activating mutations within fibroblast growth factor receptor 3 ( FGFR3 ) , a receptor tyrosine kinase , are responsible for human skeletal dysplasias including achondroplasia and the neonatal lethal syndromes , Thanatophoric Dysplasia ( TD ) type I and II .
FGFR3 geneGene encodes gene productFGFR3 protein, human
Nordihydroguaiaretic acid inhibits an activated fibroblast growth factor receptor 3 mutant and blocks downstream signaling in multiple myeloma cells . Activating mutations within fibroblast growth factor receptor 3 ( FGFR3 ) , a receptor tyrosine kinase , are responsible for human skeletal dysplasias including achondroplasia and the neonatal lethal syndromes , Thanatophoric Dysplasia ( TD ) type I and II .
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