Norcantharidin preferentially induces apoptosis in human leukemic Jurkat cells without affecting viability of normal blood mononuclear cells.

@article{Liao2007NorcantharidinPI,
  title={Norcantharidin preferentially induces apoptosis in human leukemic Jurkat cells without affecting viability of normal blood mononuclear cells.},
  author={H. T. Liao and Shu-Li Su and Yu-Jen Chen and Chin-Hung Chou and Cheng-Deng Kuo},
  journal={Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association},
  year={2007},
  volume={45 9},
  pages={1678-87}
}
Norcantharidin (NCTD) is known to have anti-cancer potentials. The aim of this study was to assess the apoptosis-inducing effect of NCTD on human leukemic Jurkat cells. We found that NCTD preferentially inhibited the growth of Jurkat cells in a dose- and time-dependent manner, but not the growth of normal blood mononuclear cells (MNC). Pretreatment with agonistic (CH-11) and antagonistic (ZB4) Fas antibodies on Jurkat cells showed that NCTD-induced apoptosis might not involve Fas-FasL signaling… CONTINUE READING