Norcantharidin enhances bortezomib-antimyeloma activity in multiple myeloma cells in vitro and in nude mouse xenografts.

@article{Du2013NorcantharidinEB,
  title={Norcantharidin enhances bortezomib-antimyeloma activity in multiple myeloma cells in vitro and in nude mouse xenografts.},
  author={Heng-fei Du and Lu-jia Yu and Yan-feng Meng and H Lv and Jianbo Meng and Xiao-ning Song and Jin-qiao Zhang},
  journal={Leukemia & lymphoma},
  year={2013},
  volume={54 3},
  pages={607-18}
}
Norcantharidin (NCTD), the demethylated analog of the Chinese medicine cantharidin, exhibits anti-myeloma activity by inactivating nuclear factor-κB (NF-κB), which is implicated in multiple myeloma (MM) cell survival and resistance to bortezomib (BTZ). We investigated whether NCTD could potentiate the anti-tumor activity of BTZ in MM. NCTD inhibited the proliferation of MM cells and potentiated the anti-myeloma effects of BTZ by down-regulating IKKα and p-IκBα, which induced the accumulation of… CONTINUE READING
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