Noradrenergic stimulation of mitochondriogenesis in brown adipocytes differentiating in culture.

@article{Nchad1987NoradrenergicSO,
  title={Noradrenergic stimulation of mitochondriogenesis in brown adipocytes differentiating in culture.},
  author={M N{\'e}chad and Jan Nedergaard and Barbara A Cannon},
  journal={The American journal of physiology},
  year={1987},
  volume={253 6 Pt 1},
  pages={C889-94}
}
The ability of adrenergic agents to promote the differentiation and especially the mitochondriogenesis of brown fat precursor cells, grown in culture, was investigated. These cells begin to differentiate during the days preceding confluence. We found here that, already during the early growth phase, the cultures (essentially precursor cells and preadipocytes at this stage) show increased cyclic AMP (cAMP) levels when acutely stimulated with norepinephrine (NE). The cultured cells were therefore… CONTINUE READING

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