Noradrenergic-serotonergic interactions and nociception in the rat.

@article{Archer1986NoradrenergicserotonergicIA,
  title={Noradrenergic-serotonergic interactions and nociception in the rat.},
  author={Trevor Archer and G{\"o}sta Jonsson and B. G. Minor and C. T. Post},
  journal={European journal of pharmacology},
  year={1986},
  volume={120 3},
  pages={295-307}
}
Spinal noradrenaline (NA) depletion in rats, via either systemic N-2-chloroethyl-N-ethyl-2-bromobenzylamine (DSP4) or intrathecal 6-hydroxydopamine (6-OHDA), reversed and/or abolished the analgesic effects of the 5-hydroxytryptamine (5-HT) agonists, 5-methoxy-N,N-dimethyltryptamine (5-MeODMT) and p-chloroamphetamine (PCA), in shock titration, hot-plate and tail-flick measures of pain sensitivity. Spinal NA depletion also abolished the analgesic effects of 5-HT itself, administered intrathecally… CONTINUE READING

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