Noradrenergic modulation of cortical acetylcholine release is both direct and gamma-aminobutyric acid-mediated.

@article{Beani1986NoradrenergicMO,
  title={Noradrenergic modulation of cortical acetylcholine release is both direct and gamma-aminobutyric acid-mediated.},
  author={Lorenzo Beani and Sergio Tanganelli and Tiziana Antonelli and Clementina Bianchi},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1986},
  volume={236 1},
  pages={230-6}
}
The effect of norepinephrine (NE) on the outflow of gamma-aminobutyric acid (GABA) as well as the influence of endogenous GABA on NE-induced inhibition of acetylcholine (ACh) release have been investigated in guinea-pig cortical slices, in order to clarify the role of this amino acid in the noradrenergic control of the cholinergic signal. NE in the range of 9 to 30 microM increased GABA outflow from unstimulated slices, doubling it at 30 microM. This effect was antagonized by prazosin (0.1… CONTINUE READING