Noradrenergic inhibition of synaptic transmission between mitral and granule cells in mammalian olfactory bulb cultures.

@article{Trombley1992NoradrenergicIO,
  title={Noradrenergic inhibition of synaptic transmission between mitral and granule cells in mammalian olfactory bulb cultures.},
  author={Paul Q. Trombley and Gordon M. Shepherd},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1992},
  volume={12 10},
  pages={3985-91}
}
Noradrenergic modulation of the glutamatergic-GABAergic synapses between mitral/tufted (M/T) and granule cells has been implicated in some forms of olfactory learning (Brennan et al., 1990). Norepinephrine (NE) has been shown to disinhibit mitral cells (Jahr and Nicoll, 1982), but its site of action is not well defined. The effects of NE on synaptic transmission between monosynaptically coupled pairs of mitral and granule cells have been examined using primary culture and whole-cell recording… CONTINUE READING