Noradrenergic effects in tardive dyskinesia, akathisia and pseudoparkinsonism via the limbic system and basal ganglia.

@article{Wilbur1988NoradrenergicEI,
  title={Noradrenergic effects in tardive dyskinesia, akathisia and pseudoparkinsonism via the limbic system and basal ganglia.},
  author={R H Wilbur and F A Kulik and Anna Kulik},
  journal={Progress in neuro-psychopharmacology & biological psychiatry},
  year={1988},
  volume={12 6},
  pages={849-64}
}
1. This paper proposes that the neuropsychiatric symptoms of tardive dyskinesia, akathisia and pseudoparkinsonian tremor are modulated by a noradrenergic pathway that projects from the locus coeruleus to the limbic system. 2. The proposed pathway is found to the consistent with neuroanatomical and neurochemical data in the literature. 3. The proposed pathway is found to be clinically consistent with observations by ourselves and others on the efficacy of clonidine and beta-adrenoreceptor… CONTINUE READING