Noradrenergic depression of synaptic responses in hippocampus of rat: evidence for mediation by alpha 1-receptors.

@article{Mynlieff1988NoradrenergicDO,
  title={Noradrenergic depression of synaptic responses in hippocampus of rat: evidence for mediation by alpha 1-receptors.},
  author={M Mynlieff and Thomas V. Dunwiddie},
  journal={Neuropharmacology},
  year={1988},
  volume={27 4},
  pages={391-8}
}
Norepinephrine (NE) has been shown to have a biphasic effect on evoked potentials in the CA1 region of the hippocampus of the rat in vitro, with a beta receptor mediating an increase and an alpha receptor eliciting a decrease in the amplitude of the population spike. The purpose of this study was to use selective alpha-adrenergic agonists and antagonists to determine the subtype of receptor mediating the depressant response of NE. The present investigations demonstrated that the selective alpha… CONTINUE READING

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