Noradrenergic antagonism of the P13 and N40 components of the rat auditory evoked potential

@article{Keedy2006NoradrenergicAO,
  title={Noradrenergic antagonism of the P13 and N40 components of the rat auditory evoked potential},
  author={Sarah K. Keedy and Megan Marlow-O’Connor and Beth Beenken and Jill M. Dorflinger and Marc S. Abel and Roland J. Erwin},
  journal={Psychopharmacology},
  year={2006},
  volume={190},
  pages={117-125}
}
Two rat auditory evoked potential (AEP) components P13 and N40 are suggested as analogues to the human P50, which has abnormal suppression properties in schizophrenia. However, P50 likely reflects neural activity from several different brain areas. Studies examining each of these components in the rat model have proposed circuitry that involves α2 norepinephrine (NE) receptors, and different disruption effects are predicted depending on whether effects are presynaptic or postsynaptic. The aim… CONTINUE READING