Noradrenergic and dopaminergic activity in the hypothalamic paraventricular nucleus after naloxone-induced morphine withdrawal.

@article{Fuertes2000NoradrenergicAD,
  title={Noradrenergic and dopaminergic activity in the hypothalamic paraventricular nucleus after naloxone-induced morphine withdrawal.},
  author={G Fuertes and Mar{\'i}a Luisa Laorden and M Victoria Milan{\'e}s},
  journal={Neuroendocrinology},
  year={2000},
  volume={71 1},
  pages={60-7}
}
Previous research has shown an increase in hypothalamo-pituitary-adrenal axis activity following naloxone administration to morphine-dependent rats. In the present study, we investigated the adaptive changes in the noradrenaline (NA) and dopamine (DA) systems in the hypothalamic paraventricular nucleus (PVN) during morphine dependence and withdrawal. Additionally, we examined the possible change in 3',5'-cyclic adenosine monophosphate (cAMP) levels in that nucleus under the same conditions… CONTINUE READING

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