Noradrenergic abnormalities in the genetically epilepsy-prone rat.


The genetically epilepsy-prone rat (GEPR) has central nervous system noradrenergic deficits as compared to normal rats. It is possible that these deficits contribute to seizure predisposition because they are exhibited by seizure-naive as well as by seizure-experienced GEPRs. On the basis of pharmacological studies, it is hypothesized that there is an… (More)


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@article{Jobe1994NoradrenergicAI, title={Noradrenergic abnormalities in the genetically epilepsy-prone rat.}, author={Phillip C. Jobe and Pabithra Kumar Mishra and Ronald A. Browning and Cheng Liang Wang and Leah E Adams-Curtis and Kwang Ho Ko and John W. Dailey}, journal={Brain research bulletin}, year={1994}, volume={35 5-6}, pages={493-504} }