Noradrenergic Mechanisms in Cocaine-Induced Reinstatement of Drug Seeking in Squirrel Monkeys

@article{Platt2007NoradrenergicMI,
  title={Noradrenergic Mechanisms in Cocaine-Induced Reinstatement of Drug Seeking in Squirrel Monkeys},
  author={Donna M Platt and James K. Rowlett and Roger D. Spealman},
  journal={Journal of Pharmacology and Experimental Therapeutics},
  year={2007},
  volume={322},
  pages={894 - 902}
}
Norepinephrine (NE) uptake and NE receptor mechanisms play important modulating roles in the discriminative stimulus and stimulant effects of cocaine. The present study investigated the role of NE mechanisms in cocaine priming-induced reinstatement of extinguished drug seeking. Squirrel monkeys (Saimiri sciureus) were trained to stability under a second-order fixed interval, fixed ratio schedule of drug self-administration in which operant responding was maintained jointly by i.v. cocaine… 
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Interactions between a subpopulation of κ opioid receptors and central corticotropin-releasing factor and noradrenergic stress systems in the reinstatement of cocaine seeking induced by κ agonists are pointed to.
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It is suggested that stress- induced reinstatement requires noradrenergic signaling through β-2 ARs and that cocaine-induced reinstatement does not require AR activation, even though stimulation of central nor adrenergic neurotransmission is sufficient to reinstate.
Effects of Pharmacologic Dopamine β-Hydroxylase Inhibition on Cocaine-Induced Reinstatement and Dopamine Neurochemistry in Squirrel Monkeys
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Overall, the reported behavioral effects of DBH inhibition in rodent models of relapse did not extend to nonhuman primates under the conditions used in the current studies.
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Data suggest that greater potency for NE relative to dopamine release does not interfere with the ability of a monoamine releaser to produce cocaine-like discriminative effects but that increased serotonin release may have an inhibitory effect.
A Study of Corticotropin-releasing Factor-catecholamine Interactions in the Reinstatement of Cocaine Seeking in Rats
TLDR
Findings suggest a functional interaction between NA and CRF systems in mediating stress-induced reinstatement of cocaine seeking, whereby activation of CRF receptors occurs subsequent to, and downstream of, the sites of action of NA.
Selective Norepinephrine Reuptake Inhibition by Atomoxetine Prevents Cue-Induced Heroin and Cocaine Seeking
Corticosterone Potentiation of Cocaine-Induced Reinstatement of Conditioned Place Preference in Mice is Mediated by Blockade of the Organic Cation Transporter 3
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T pretreatment of male C57/BL6 mice with corticosterone potentiated cocaine-primed reinstatement of extinguished cocaine-induced conditioned place preference and established OCT3 function as an important determinant of susceptibility to cocaine use.
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Interaction between noradrenaline and corticotrophin-releasing factor in the reinstatement of cocaine seeking in the rat
TLDR
A functional interaction between NA and CRF systems in mediating stress-induced reinstatement of cocaine seeking is suggested, whereby activation of CRF receptors occurs subsequent to, and downstream of, the sites of action of NA.
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