Noradrenergic Mechanisms in Cocaine-Induced Reinstatement of Drug Seeking in Squirrel Monkeys
@article{Platt2007NoradrenergicMI, title={Noradrenergic Mechanisms in Cocaine-Induced Reinstatement of Drug Seeking in Squirrel Monkeys}, author={Donna M Platt and James K. Rowlett and Roger D. Spealman}, journal={Journal of Pharmacology and Experimental Therapeutics}, year={2007}, volume={322}, pages={894 - 902} }
Norepinephrine (NE) uptake and NE receptor mechanisms play important modulating roles in the discriminative stimulus and stimulant effects of cocaine. The present study investigated the role of NE mechanisms in cocaine priming-induced reinstatement of extinguished drug seeking. Squirrel monkeys (Saimiri sciureus) were trained to stability under a second-order fixed interval, fixed ratio schedule of drug self-administration in which operant responding was maintained jointly by i.v. cocaine…
44 Citations
Attenuation of cocaine-induced reinstatement of drug seeking in squirrel monkeys: kappa opioid and serotonergic mechanisms
- Psychology, BiologyPsychopharmacology
- 2009
The capacity of kappa opioid agonists to increase extracellular 5-HT levels may at least partially underlie kappa agonist-induced modulation of cocaine seeking.
κ Agonist-Induced Reinstatement of Cocaine Seeking in Squirrel Monkeys: A Role for Opioid and Stress-Related Mechanisms
- Biology, PsychologyJournal of Pharmacology and Experimental Therapeutics
- 2007
Interactions between a subpopulation of κ opioid receptors and central corticotropin-releasing factor and noradrenergic stress systems in the reinstatement of cocaine seeking induced by κ agonists are pointed to.
Involvement of Noradrenergic Neurotransmission in the Stress- but not Cocaine-Induced Reinstatement of Extinguished Cocaine-Induced Conditioned Place Preference in Mice: Role for β-2 Adrenergic Receptors
- Biology, PsychologyNeuropsychopharmacology
- 2010
It is suggested that stress- induced reinstatement requires noradrenergic signaling through β-2 ARs and that cocaine-induced reinstatement does not require AR activation, even though stimulation of central nor adrenergic neurotransmission is sufficient to reinstate.
Effects of Pharmacologic Dopamine β-Hydroxylase Inhibition on Cocaine-Induced Reinstatement and Dopamine Neurochemistry in Squirrel Monkeys
- Biology, PsychologyThe Journal of Pharmacology and Experimental Therapeutics
- 2014
Overall, the reported behavioral effects of DBH inhibition in rodent models of relapse did not extend to nonhuman primates under the conditions used in the current studies.
Cocaine-like discriminative stimulus effects of “norepinephrine-preferring” monoamine releasers: time course and interaction studies in rhesus monkeys
- Biology, PsychologyPsychopharmacology
- 2017
Data suggest that greater potency for NE relative to dopamine release does not interfere with the ability of a monoamine releaser to produce cocaine-like discriminative effects but that increased serotonin release may have an inhibitory effect.
A Study of Corticotropin-releasing Factor-catecholamine Interactions in the Reinstatement of Cocaine Seeking in Rats
- Biology, Psychology
- 2012
Findings suggest a functional interaction between NA and CRF systems in mediating stress-induced reinstatement of cocaine seeking, whereby activation of CRF receptors occurs subsequent to, and downstream of, the sites of action of NA.
Selective Norepinephrine Reuptake Inhibition by Atomoxetine Prevents Cue-Induced Heroin and Cocaine Seeking
- Biology, PsychologyBiological Psychiatry
- 2011
Corticosterone Potentiation of Cocaine-Induced Reinstatement of Conditioned Place Preference in Mice is Mediated by Blockade of the Organic Cation Transporter 3
- Biology, PsychologyNeuropsychopharmacology
- 2017
T pretreatment of male C57/BL6 mice with corticosterone potentiated cocaine-primed reinstatement of extinguished cocaine-induced conditioned place preference and established OCT3 function as an important determinant of susceptibility to cocaine use.
α1-Noradrenergic system role in increased motivation for cocaine intake in rats with prolonged access
- Biology, PsychologyEuropean Neuropsychopharmacology
- 2008
Interaction between noradrenaline and corticotrophin-releasing factor in the reinstatement of cocaine seeking in the rat
- Biology, PsychologyPsychopharmacology
- 2008
A functional interaction between NA and CRF systems in mediating stress-induced reinstatement of cocaine seeking is suggested, whereby activation of CRF receptors occurs subsequent to, and downstream of, the sites of action of NA.
References
SHOWING 1-10 OF 56 REFERENCES
Pharmacological Blockade of α2-Adrenoceptors Induces Reinstatement of Cocaine-Seeking Behavior in Squirrel Monkeys
- Psychology, BiologyNeuropsychopharmacology
- 2004
The results show that pharmacological blockade of α2-adrenoceptors can induce reinstatement of cocaine-seeking behavior and characteristic stress responses in squirrel monkeys, providing a potentially useful model of stress-induced relapse to drug seeking.
Noradrenergic involvement in the discriminative stimulus effects of cocaine in squirrel monkeys.
- Biology, PsychologyThe Journal of pharmacology and experimental therapeutics
- 1995
The results support a role for norepinephrine uptake and alpha-1 adrenoceptor mechanisms in the DS effects of cocaine, possibly reflecting a facilitory noradrenergic influence on mesocorticolimbic dopamine activity.
Prazosin, an α-1 Adrenergic Antagonist, Reduces Cocaine-Induced Reinstatement of Drug-Seeking
- Psychology, BiologyBiological Psychiatry
- 2005
Alpha-2 Adrenergic Receptor Agonists Block Stress-Induced Reinstatement of Cocaine Seeking
- Biology, PsychologyNeuropsychopharmacology
- 2000
The role of monoamine uptake in the discriminative stimulus effects of cocaine and related compounds1
- Psychology, BiologyBehavioural pharmacology
- 1993
Results reported previously suggest that inhibition of DA uptake is involved to a greater extent than either NE or 5-HT uptake in the discriminative stimulus properties of cocaine and related compounds.
Evaluation of the role of norepinephrine in the reinforcing effects of psychomotor stimulants in rhesus monkeys
- Biology, PsychologyPharmacology Biochemistry and Behavior
- 1987
Role of the hypothalamic-pituitary-adrenal axis in reinstatement of cocaine-seeking behavior in squirrel monkeys
- Biology, PsychologyPsychopharmacology
- 2003
It is suggested that activation of the HPA axis is neither necessary nor sufficient for reinstatement of cocaine-seeking behavior in this non-human primate model of cocaine relapse.
Systemic administration of a dopamine, but not a serotonin or norepinephrine, transporter inhibitor reinstates cocaine seeking in the rat
- Biology, PsychologyBehavioural Brain Research
- 2006
Blockade of Stress-Induced But Not Cocaine-Induced Reinstatement by Infusion of Noradrenergic Antagonists into the Bed Nucleus of the Stria Terminalis or the Central Nucleus of the Amygdala
- Biology, PsychologyThe Journal of Neuroscience
- 2002
The data suggest that stress-induced NA activation in the BNST and in the region of the CeA is critical to relapse to drug seeking induced by stress but not to relapse induced by priming injections of cocaine, and it is hypothesized that NA activity leads to activation of corticotropin-releasing factor neurons in these regions.
Discriminative stimulus properties of cocaine: enhancement by monoamine reuptake blockers.
- Biology, PsychologyThe Journal of pharmacology and experimental therapeutics
- 1998
Analysis of the relationship between behavioral and in vitro biochemical potencies indicated that inhibition of DA and 5-HT transport is responsible for the cocaine-enhancing effects of the monoamine reuptake blockers, and suggested that NE interactions may be relatively less important in the rat.