Noradrenaline systems in the hypothalamus, amygdala and locus coeruleus are involved in the provocation of anxiety: basic studies.

@article{Tanaka2000NoradrenalineSI,
  title={Noradrenaline systems in the hypothalamus, amygdala and locus coeruleus are involved in the provocation of anxiety: basic studies.},
  author={Masahiro Tanaka and Mizuho Yoshida and Hirofumi Emoto and Hiromitsu Ishii},
  journal={European journal of pharmacology},
  year={2000},
  volume={405 1-3},
  pages={397-406}
}
A variety of stressful events, including emotional stress, cause a marked increase in noradrenaline release in several brain regions, and especially in the hypothalamus, amygdala and locus coeruleus, in the rat brain. These findings suggest that an increased noradrenaline release could be closely related to the provocation of negative emotions such as anxiety and/or fear. In order to confirm this hypothesis, we carried out several studies. Diazepam, a typical benzodiazepine anxiolytic… CONTINUE READING