Noradrenaline neurotoxin DSP-4 effects on sleep and brain temperature in the rat

@article{Gonzlez1998NoradrenalineND,
  title={Noradrenaline neurotoxin DSP-4 effects on sleep and brain temperature in the rat},
  author={M{\'o}nica M C Gonz{\'a}lez and Gabriel Debilly and Jean-louis Valatx},
  journal={Neuroscience Letters},
  year={1998},
  volume={248},
  pages={93-96}
}
N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4) has a selective degenerative effect on noradrenergic fibers originating from locus coeruleus (LC) neurons. In the present study, we studied its effect on vigilance states and brain temperature by continuous recordings for periods of 1-5 days and 2-4 weeks following DSP-4 treatment. On the first day, paradoxical sleep duration was significantly decreased (-67%, P < 0.05), slow-wave sleep (SWS) duration increased (+16%, P < 0.05) up to 48 h… CONTINUE READING

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