Noradrenaline inhibition of Ca2+ channels and secretion in single patch-clamped insulinoma cells.

@article{Sher1996NoradrenalineIO,
  title={Noradrenaline inhibition of Ca2+ channels and secretion in single patch-clamped insulinoma cells.},
  author={Elizabeth Sher and Agnese Codignola and Mike Rogers and Jeffrey H Richmond},
  journal={FEBS letters},
  year={1996},
  volume={385 3},
  pages={176-80}
}
Noradrenaline effects on voltage-operated calcium channels and exocytosis were studied, for the first time, in single patch-clamped RINm5F insulin-secreting cells. Noradrenaline, despite small and variable inhibition of calcium currents, strongly inhibited the increase in membrane capacitance (a measure of exocytosis) stimulated by both step depolarizations… CONTINUE READING