Noradrenaline blocks accommodation of pyramidal cell discharge in the hippocampus

@article{Madison1982NoradrenalineBA,
  title={Noradrenaline blocks accommodation of pyramidal cell discharge in the hippocampus},
  author={Daniel V. Madison and Roger A Nicoll},
  journal={Nature},
  year={1982},
  volume={299},
  pages={636-638}
}
The hippocampus, as well as a variety of other brain regions, is known to receive a diffuse projection of noradrenaline (NA) containing fibres which originates in the brain stem1–4. Although there is considerable evidence for the involvement of this system in a variety of behaviours5–7, the precise cellular actions of NA are poorly understood. Early studies emphasized the direct inhibitory effects of NA8–12; more recent experiments have shown that at several sites, NA, or stimulation of NA… CONTINUE READING