Nootropic Activity of BacoMind, An Enriched Phytochemical Composition from Bacopa monnieri

  title={Nootropic Activity of BacoMind, An Enriched Phytochemical Composition from Bacopa monnieri},
  author={Sanjay Kasture and Veena Sanjay Kasture and A. J. Joshua and A. Damodaran and A. Amit},
  journal={Journal of Natural Remedies},
The objective of this study was to evaluate the nootropic activity of BacoMind TM , an enriched phytochemical composition from Bacopa monnieri , in different learning and memory paradigms viz ., elevated plus maze, passive shock avoidance test and object recognition test. BacoMind was administered for 7 days at the dose of 40, 60 and 80 mg/kg to mice in elevated plus maze and passive shock avoidance test and 27, 40 and 54 mg/kg to rats in object recognition test. Scopolamine (0.3 mg/kg) was… 

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Pharmacol . Biochem . Behav

  • 2002

The New Eng

  • J. Med
  • 2005

Proceedings of the fourth conference on neurobiology learning memory , Abstract No . 79

  • 1990

Tomer Milestein, Eilon Vaadia

  • Eur. J. Neuroscience
  • 2005

Molecular aspects of Asian medicines

  • 1999

Siva Sankar DV (Ed.) Molecular aspects of Asian medicines, PJD publications: New York

  • Eur. J. Pharmacol
  • 1997

Indian medicinal plants, Bhishen Singh and Mehendra Paul Singh: Delhi

  • 1935