Nootropic Activity of BacoMind, An Enriched Phytochemical Composition from Bacopa monnieri

  title={Nootropic Activity of BacoMind, An Enriched Phytochemical Composition from Bacopa monnieri},
  author={Sanjay Kasture and Veena Sanjay Kasture and A. J. Joshua and A. Damodaran and A. Amit},
  journal={Journal of Natural Remedies},
The objective of this study was to evaluate the nootropic activity of BacoMind TM , an enriched phytochemical composition from Bacopa monnieri , in different learning and memory paradigms viz ., elevated plus maze, passive shock avoidance test and object recognition test. BacoMind was administered for 7 days at the dose of 40, 60 and 80 mg/kg to mice in elevated plus maze and passive shock avoidance test and 27, 40 and 54 mg/kg to rats in object recognition test. Scopolamine (0.3 mg/kg) was… Expand
Evaluation of anxiolytic properties of BacoMind extract of plant Bacopa monnieri Linn. in comparison with diazepam in rodent model
Anxiety is a psychological and physiological state characterized by somatic, emotional, cognitive, and behavioral components, associated with significant disability which has a negative impact on the quality of life. Expand
Experimental and Clinical Evaluation of Nootropic Activity of Bacopa monniera Linn. (Brahmi)
Extracts as well as the bacoside preparation have been found safe and well tolerated in healthy volunteers in single dose or chronic administration for several weeks in a number of double blind placebo controlled studies in India and abroad. Expand
Indigofera tinctoria Linn (Fabaceae) attenuates cognitive and behavioral deficits in scopolamine-induced amnesic mice
Purpose: To investigate the cognition-enhancing effects of aqueous extract of Indigofera tinctoria Linn (ITE, Fabaceae) in experimental amnesic mice. Methods : Scopolamine (2 mg/kg, i.p.) was used toExpand
Memory enhancing activity of Lawsonia inermis Linn. leaves against scopolamine induced memory impairment in Swiss albino mice
The objective of the present study was to evaluate the memory enhancing activity of Lawsonia inermis Linn. leaves against scopolamine induced amnesia by elevated plus maze and Y-maze test. TheExpand
HPTLC Analysis with the Effect ofBacopa monnieri, Evolvulus alsinoidesandTinospora cordifoliaagainst Scopolamine-Induced Amnesic Rats
Findings suggested that the content of extracts of these compounds has an antioxidant property in the brain and also, BME, EAE, and TCE in the CEPs provide a synergistic effect on behavioral assessment. Expand
Antiamnesic Potential of Coccinia indica (Linn.) Extract: A Mechanism Based Study
The results indicate that ethanolic extract of Coccinia indica might be a useful as natural source of antiamnesic drug to improve learning and memory deficit associated symptoms of dementia and Alzheimer’s patients. Expand
Safety evaluation of BacoMind in healthy volunteers: a phase I study.
BacoMind was found to meet the safety criteria at the dose administered for the given duration of trial period in healthy adult volunteers and did not indicate any untoward effects in any of the treated volunteers. Expand
Lavandula stoechas (L) a Very Potent Antioxidant Attenuates Dementia in Scopolamine Induced Memory Deficit Mice
The findings suggest that L. stoechas stabilizes memory by enhancing cholinergic neurotransmission and by providing defense against oxidative stress in mice brain. Expand
Efficacy of Ocimum sanctum for relieving stress: a preclinical study.
Ocimum sanctum possess significant antistress activity but the magnitude and efficacy for relieving stress is less, when compare to standard anxiolytic agent, i.e. Alprazolam. Expand
Elucidation of Molecular Mechanism(s) of Cognition Enhancing Activity of Bacomind®: A Standardized Extract of Bacopa Monnieri
BacoMind (BM), a standardized extract of B. monnieri, was found to inhibit three enzymes namely, Catechol-O-methyl transferase (COMT), Prolyl endopeptidase (PEP), and Poly (ADP-ribose) polymerase (PARP) and exhibited an antagonistic effect on5-HT 6 and 5-HT 2A receptors. Expand


Segregation between acquisition and long‐term memory in sensorimotor learning
The results show that learning one task led to proactive interference to acquisition of the second, however, this interference was not accompanied by retroactive interference to consolidation of the first task, indicating that acquisition and consolidation can be uncoupled. Expand
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