Nonylphenol, an environmental estrogen, affects voltage-gated K⁺ currents and L-type Ca²⁺ currents in a non-monotonic manner in GH₃ pituitary cells.

Abstract

We have investigated the characteristics of voltage-gated K(+) channels and L-type Ca(2+) channels in GH3 rat pituitary cells and the effects of the xenoestrogen (XEs) nonylphenol (NP) on these ion channel currents. Our results have shown that the lower concentrations (10(-15)-10(-14)M) of NP decreased the amplitudes of voltage-gated K(+) currents (IKv) and activated L-type Ca(2+) currents (ICa-L) by reducing half-activation membrane potentials of activation kinetics curves. However, the higher concentrations (10(-10)-10(-9)M) of NP increased the amplitudes of IKv and inhibited ICa-L by reducing the peak values of ICa-L. Thus, NP affects IKv and ICa-L in an opposite and non-monotonic manner.

DOI: 10.1016/j.toxlet.2013.01.016

5 Figures and Tables

Cite this paper

@article{Gao2013NonylphenolAE, title={Nonylphenol, an environmental estrogen, affects voltage-gated K⁺ currents and L-type Ca²⁺ currents in a non-monotonic manner in GH₃ pituitary cells.}, author={Qinghua Gao and Tong Zhu and Feng Guo and Shizheng Huang and Huiyuan Hu and Rui Feng and Li-Ying Hao}, journal={Toxicology letters}, year={2013}, volume={218 2}, pages={137-43} }