Nonviral vectors in the new millennium: delivery barriers in gene transfer.

@article{Nishikawa2001NonviralVI,
  title={Nonviral vectors in the new millennium: delivery barriers in gene transfer.},
  author={Motoaki Nishikawa and Li-yun Huang},
  journal={Human gene therapy},
  year={2001},
  volume={12 8},
  pages={861-70}
}
Development of an efficient method for introducing a therapeutic gene into target cells in vivo is the key issue in treating genetic and acquired diseases by gene therapy. To this end, various nonviral vectors have been designed and developed, and some of them are in clinical trials. The simplest approach is naked DNA injection into local tissues or systemic circulation. Physical (gene gun, electroporation) and chemical (cationic lipid or polymer) approaches have also been utilized to improve… CONTINUE READING

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