Nonviral gene delivery to the rat kidney with polyethylenimine.

  title={Nonviral gene delivery to the rat kidney with polyethylenimine.},
  author={A Boletta and Ariela Benigni and Joachim Lutz and Giuseppe Remuzzi and Marco R. Soria and Lucia Monaco},
  journal={Human gene therapy},
  volume={8 10},
The aim of this study was to establish a nonviral method for gene delivery to the rat kidney. To this purpose, a panel of reagents was tested, including a monocationic lipid, DOTAP, a polycationic lipid, DOGS (or Transfectam), and three different forms of the cationic polymer polyethylenimine (PEI). A comparison among these compounds was performed in vivo, using luciferase as reporter gene. Complexes containing 10 microg of DNA were injected into the left renal artery of rats and allowed to… CONTINUE READING


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