Nonuniform elasticity of titin in cardiac myocytes: a study using immunoelectron microscopy and cellular mechanics.

@article{Granzier1996NonuniformEO,
  title={Nonuniform elasticity of titin in cardiac myocytes: a study using immunoelectron microscopy and cellular mechanics.},
  author={Henk L. M. Granzier and Michiel Helmes and K{\'a}roly Trombit{\'a}s},
  journal={Biophysical journal},
  year={1996},
  volume={70 1},
  pages={430-42}
}
Titin (also known as connectin) is a muscle-specific giant protein found inside the sarcomere, spanning from the Z-line to the M-line. The I-band segment of titin is considered to function as a molecular spring that develops tension when sarcomeres are stretched (passive tension). Recent studies on skeletal muscle indicate that it is not the entire I-band… CONTINUE READING