Nontoxic, Hydrophilic Cationic Polymers-Identified as Class of Antimicrobial Polymers.

@article{Strassburg2015NontoxicHC,
  title={Nontoxic, Hydrophilic Cationic Polymers-Identified as Class of Antimicrobial Polymers.},
  author={Arne Strassburg and Frauke Kracke and Julia Wenners and Anna Jemeljanova and Jannis Kuepper and Hanne Petersen and Joerg C Tiller},
  journal={Macromolecular bioscience},
  year={2015},
  volume={15 12},
  pages={1710-23}
}
Amphiphilic polycations are an alternative to biocides but also toxic to mammalian cells. Antimicrobially active hydrophilic polycations based on 1,4-dibromo-2-butene and tetramethyl-1,3-propanediamine named PBI are not hemotoxic for porcine red blood cells with a hemocytotoxicity (HC50) of more than 40,000 μg · mL(-1). They are quickly killing bacterial cells at their MIC (minimal inhibitory concentration). The highest found selectivity HC50 /MIC is more than 20,000 for S. epidermidis… CONTINUE READING
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