Nontargeted stressful effects in normal human fibroblast cultures exposed to low fluences of high charge, high energy (HZE) particles: kinetics of biologic responses and significance of secondary radiations.

@article{Gonon2013NontargetedSE,
  title={Nontargeted stressful effects in normal human fibroblast cultures exposed to low fluences of high charge, high energy (HZE) particles: kinetics of biologic responses and significance of secondary radiations.},
  author={G{\'e}raldine Gonon and Jean-Emmanuel Groetz and Sonia M. de Toledo and Roger William Howell and Michel Fromm and Edouard I Azzam},
  journal={Radiation research},
  year={2013},
  volume={179 4},
  pages={
          444-57
        }
}
The induction of nontargeted stressful effects in cell populations exposed to low fluences of high charge (Z) and high energy (E) particles is relevant to estimates of the health risks of space radiation. We investigated the up-regulation of stress markers in confluent normal human fibroblast cultures exposed to 1,000 MeV/u iron ions [linear energy transfer (LET) ∼151 keV/μm] or 600 MeV/u silicon ions (LET ∼50 keV/μm) at mean absorbed doses as low as 0.2 cGy, wherein 1-3% of the cells were… CONTINUE READING

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