Nontarget Analysis Reveals a Bacterial Metabolite of Pyrene Implicated in the Genotoxicity of Contaminated Soil after Bioremediation.

@article{Tian2017NontargetAR,
  title={Nontarget Analysis Reveals a Bacterial Metabolite of Pyrene Implicated in the Genotoxicity of Contaminated Soil after Bioremediation.},
  author={Zhenyu Tian and Avram Gold and Jun Nakamura and Zhenfa Zhang and Joaquim Vila and David R Singleton and Leonard B. Collins and Michael D Aitken},
  journal={Environmental science \& technology},
  year={2017},
  volume={51 12},
  pages={
          7091-7100
        }
}
Bioremediation is an accepted technology for cleanup of soil contaminated with polycyclic aromatic hydrocarbons (PAHs), but it can increase the genotoxicity of the soil despite removal of the regulated PAHs. Although polar biotransformation products have been implicated as causative genotoxic agents, no specific product has been identified. We pursued a nontarget analytical approach combining effect-directed analysis (EDA) and metabolite profiling to compare extracts of PAH-contaminated soil… Expand
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