Nonsynonymous Polymorphisms of Histamine-Metabolising Enzymes in Patients with Parkinson’s Disease

@article{Agndez2007NonsynonymousPO,
  title={Nonsynonymous Polymorphisms of Histamine-Metabolising Enzymes in Patients with Parkinson’s Disease},
  author={Jos{\'e} A. G. Ag{\'u}ndez and Antonio Luengo and Oscar Herr{\'a}ez and Carmen Mart{\'i}nez and Hortensia Alonso-Navarro and F{\'e}lix Javier Jim{\'e}nez-Jim{\'e}nez and Elena Garcia-Martin},
  journal={NeuroMolecular Medicine},
  year={2007},
  volume={10},
  pages={10-16}
}
Objective    To analyze genetically based impairment in histamine-metabolising enzymes in patients with Parkinson’s disease (PD). Methods    Leukocytary DNA from 214 PD patients and a control group of 295 unrelated healthy individuals was studied for nonsynonymous histamine N-methyltransferase (HNMT) and diamine oxidase (ABP1) polymorphisms by using amplification–restriction analyses. Results    An association of the HNMT Thr105Ile polymorphism, but not of the ABP1 His645Asp polymorphism, with… CONTINUE READING

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