Nonsynaptic modulation of neuronal activity in the brain: electric currents and extracellular ions.

@article{Jefferys1995NonsynapticMO,
  title={Nonsynaptic modulation of neuronal activity in the brain: electric currents and extracellular ions.},
  author={J. Jefferys},
  journal={Physiological reviews},
  year={1995},
  volume={75 4},
  pages={
          689-723
        }
}
  • J. Jefferys
  • Published 1995
  • Biology, Medicine
  • Physiological reviews
Nonsynaptic interactions between neurons have been eclipsed by our increasingly detailed understanding of chemical synapses, but they do play significant roles in the nervous system. This review considers four classes of nonsynaptic interaction, mainly in mammalian brain. 1) Electrotonic (and chemical) coupling through gap junctions has effects during development and under some, often pathological, conditions in the mature brain. 2) Ephaptic transmission is mediated by electrical coupling… Expand
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