Nonsynaptic Glycine Receptor Activation during Early Neocortical Development

@article{Flint1998NonsynapticGR,
  title={Nonsynaptic Glycine Receptor Activation during Early Neocortical Development},
  author={Alexander C. Flint and Xiaolin Liu and Arnold R Kriegstein},
  journal={Neuron},
  year={1998},
  volume={20},
  pages={43-53}
}
Glycine receptors (GlyRs) contribute to fast inhibitory synaptic transmission in the brain stem and spinal cord. GlyR subunits are expressed in the developing neocortex, but a neurotransmitter system involving cortical GlyRs has yet to be demonstrated. Here, we show that GlyRs in immature neocortex are excitatory and activated by a nonsynaptically released… CONTINUE READING