Nonsurgical direct delivery of plasmid DNA into rat heart: time course, dose response, and the influence of different promoters on gene expression.

@article{Sarkar2002NonsurgicalDD,
  title={Nonsurgical direct delivery of plasmid DNA into rat heart: time course, dose response, and the influence of different promoters on gene expression.},
  author={Nondita Sarkar and Pontus Blomberg and Eva W{\"a}rdell and Malihe Eskandarpour and Christer Sylven and Viktor Drvota and Khalid Bin Islam},
  journal={Journal of cardiovascular pharmacology},
  year={2002},
  volume={39 2},
  pages={
          215-24
        }
}
Transfer of genes encoding therapeutic proteins into the myocardium shows great potential for treatment of coronary artery disease. To quantitatively elucidate the behavior of plasmid DNA following cardiac gene transfer, time kinetics, dose-response relationship, systemic spread to the liver, and the influence of different promoters on plasmid DNA gene expression in rat hearts were examined using a novel nonsurgical direct delivery method that enables testing of large numbers of animals… CONTINUE READING

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