Nonsteroidal antiinflammatory drugs and acute myocardial infarction in patients with no major risk factors.

@article{Jick2006NonsteroidalAD,
  title={Nonsteroidal antiinflammatory drugs and acute myocardial infarction in patients with no major risk factors.},
  author={Hershel Jick and James A Kaye and Stefan Russmann and Susan Jick},
  journal={Pharmacotherapy},
  year={2006},
  volume={26 10},
  pages={
          1379-87
        }
}
STUDY OBJECTIVE To assess the risk of long-term use of five nonsteroidal antiinflammatory drugs (NSAIDs)--rofecoxib, celecoxib, ibuprofen, naproxen, and diclofenac--in relation to acute myocardial infarction. DESIGN Five separate nested case-control studies, one for each NSAID, designed to minimize important biases present in other observational studies. Setting. University-affiliated research program. Data Source. The United Kingdom General Practice Research Database (GPRD). MEASUREMENTS… CONTINUE READING
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