Nonsteroidal antiinflammatory drug use and the risk for Parkinson's disease
@article{Chen2005NonsteroidalAD, title={Nonsteroidal antiinflammatory drug use and the risk for Parkinson's disease}, author={Honglei Chen and Eric J. Jacobs and Michael A Schwarzschild and Marjorie L McCullough and Eugenia E. Calle and Michael J. Thun and Alberto Ascherio}, journal={Annals of Neurology}, year={2005}, volume={58} }
We investigated whether nonsteroidal antiinflammatory drug use was associated with a lower risk for Parkinson's disease (PD) in a large cohort of US men and women. PD risk was lower among ibuprofen users than nonusers. Compared with nonusers, the relative risks were 0.73 for users of fewer than 2 tablets/week, 0.72 for 2 to 6.9 tablets/week, and 0.62 for 1 or more tablets/day (p trend = 0.03). No association was found between the use of aspirin, other nonsteroidal antiinflammatory drugs, or…
438 Citations
Non-steroidal anti-inflammatory drug use and the risk of Parkinson disease: A retrospective cohort study
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The proportion of NSAID or aspirin users did not differ in ET cases or controls; yet interestingly, ibuprofen use was less inET cases than in controls, raising the possibility that ibup rofen use could have a potential protective role in ET.
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The findings do not support the hypothesis that NSAIDs might decrease the risk of Parkinson disease, and the role of inflammatory processes in Parkinson disease remains unclear.
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The association between use of ibuprofen and lower PD risks, not shared by other NSAIDs or acetaminophen, suggests ib uprofen should be further investigated as a potential neuroprotective agent against PD.
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Current users of NSAIDs may be at a slightly higher risk of developing Parkinson's disease, and more studies are needed to confirm this finding.
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This case-control study did not find evidence that NSAID use reduces Parkinson’s disease risk, and positive associations observed might have been due to confounding by indication as the use was clustered in the few years before disease diagnosis.
Non-steroidal anti-inflammatory drugs and risk of Parkinson’s disease in the elderly population: a meta-analysis
- Medicine, BiologyEuropean Journal of Clinical Pharmacology
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There is no association between NSAIDs and the risk of Parkinson disease at the population level, and clinicians need to be vigilant ensuring that the use of NSAIDs remains restricted to their approved anti-inflammatory and analgesic effect.
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- Medicine, BiologyMedicine
- 2018
A dose–response meta-analysis showed that nonsteroidal anti-inflammatory drugs (NSAIDs) use was not associated with Parkinson disease risk, and the potency and the cumulative NSAIDs use did not play critical roles.
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There may be a protective effect of nonaspirin nonsteroidal anti-inflammatory drug use on risk of Parkinson disease (PD) consistent with a possible neuroinflammatory pathway in PD pathogenesis.
NSAID Use and the Risk of Parkinson’s Disease
- Medicine, PsychologyDrugs & aging
- 2009
Although the risk ratios of PD in male and female NSAID users were similar, the 95% CI for men was suggestive of a slight risk reduction, and ibuprofen may have a slight protective effect in lowering the risk of PD.
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