Nonsteroidal antiinflammatory drug use and the risk for Parkinson's disease

@article{Chen2005NonsteroidalAD,
  title={Nonsteroidal antiinflammatory drug use and the risk for Parkinson's disease},
  author={Honglei Chen and Eric J. Jacobs and Michael A Schwarzschild and Marjorie L McCullough and Eugenia E. Calle and Michael J. Thun and Alberto Ascherio},
  journal={Annals of Neurology},
  year={2005},
  volume={58}
}
We investigated whether nonsteroidal antiinflammatory drug use was associated with a lower risk for Parkinson's disease (PD) in a large cohort of US men and women. PD risk was lower among ibuprofen users than nonusers. Compared with nonusers, the relative risks were 0.73 for users of fewer than 2 tablets/week, 0.72 for 2 to 6.9 tablets/week, and 0.62 for 1 or more tablets/day (p trend = 0.03). No association was found between the use of aspirin, other nonsteroidal antiinflammatory drugs, or… 
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438 Citations
Highly Influential Citations
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Background Citations
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Methods Citations
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Results Citations
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438 Citations

Non-steroidal anti-inflammatory drug use and the risk of Parkinson disease: A retrospective cohort study
Non-Steroidal Anti-Inflammatory Drug Use and Essential Tremor
TLDR
The proportion of NSAID or aspirin users did not differ in ET cases or controls; yet interestingly, ibuprofen use was less inET cases than in controls, raising the possibility that ibup rofen use could have a potential protective role in ET.
Nonsteroidal Anti-Inflammatory Drugs and the Risk of Parkinson Disease
TLDR
The findings do not support the hypothesis that NSAIDs might decrease the risk of Parkinson disease, and the role of inflammatory processes in Parkinson disease remains unclear.
Use of ibuprofen and risk of Parkinson disease
TLDR
The association between use of ibuprofen and lower PD risks, not shared by other NSAIDs or acetaminophen, suggests ib uprofen should be further investigated as a potential neuroprotective agent against PD.
NSAID use and the risk of Parkinson's disease.
TLDR
Current users of NSAIDs may be at a slightly higher risk of developing Parkinson's disease, and more studies are needed to confirm this finding.
Use of non-steroidal anti-inflammatory drugs and risk of Parkinson’s disease: nested case-control study
TLDR
This case-control study did not find evidence that NSAID use reduces Parkinson’s disease risk, and positive associations observed might have been due to confounding by indication as the use was clustered in the few years before disease diagnosis.
Non-steroidal anti-inflammatory drugs and risk of Parkinson’s disease in the elderly population: a meta-analysis
TLDR
There is no association between NSAIDs and the risk of Parkinson disease at the population level, and clinicians need to be vigilant ensuring that the use of NSAIDs remains restricted to their approved anti-inflammatory and analgesic effect.
Nonsteroidal anti-inflammatory drugs use and risk of Parkinson disease
TLDR
A dose–response meta-analysis showed that nonsteroidal anti-inflammatory drugs (NSAIDs) use was not associated with Parkinson disease risk, and the potency and the cumulative NSAIDs use did not play critical roles.
Anti-inflammatory drugs and risk of Parkinson disease
TLDR
There may be a protective effect of nonaspirin nonsteroidal anti-inflammatory drug use on risk of Parkinson disease (PD) consistent with a possible neuroinflammatory pathway in PD pathogenesis.
NSAID Use and the Risk of Parkinson’s Disease
TLDR
Although the risk ratios of PD in male and female NSAID users were similar, the 95% CI for men was suggestive of a slight risk reduction, and ibuprofen may have a slight protective effect in lowering the risk of PD.
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