Nonsteroidal antiandrogens: a therapeutic option for patients with advanced prostate cancer who wish to retain sexual interest and function
@article{Iversen2001NonsteroidalAA, title={Nonsteroidal antiandrogens: a therapeutic option for patients with advanced prostate cancer who wish to retain sexual interest and function}, author={Peter Iversen and Ivan Melez{\'i}nek and A Schmidt}, journal={BJU International}, year={2001}, volume={87} }
The quality of life of men with prostate cancer is receiving increasing attention and, acknowledging that endocrine therapy conceptually remains a palliative treatment, many patients view the preservation of quality of life to be an equally important goal of therapy as the prolongation of survival [1]. The issue of quality of life is further emphasized by moves to initiate endocrine therapy earlier in the course of the disease and in younger men. Sexuality is an important aspect of quality of…
72 Citations
Quality of Life Aspects of Treatment Options for Localized and Locally Advanced Prostate Cancer
- MedicineEuropean Urology
- 2001
Data from two large studies of bicalutamide therapy in patients with locally advanced prostate cancer show that this non-steroidal antiandrogen is not only associated with comparable survival outcomes but significant health-related quality of life benefits, compared with castration.
An evaluation of bicalutamide in the treatment of prostate cancer
- Medicine, BiologyExpert opinion on pharmacotherapy
- 2002
Mature survival data from men with previously untreated, locally-advanced prostate cancer reveal that bicalutamide monotherapy provides survival benefits that do not differ significantly from castration, while offering important advantages with respect to the maintenance of physical capacity and sexual interest.
An evaluation of bicalutamide in the treatment of prostate cancer.
- MedicineClinical prostate cancer
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Mature survival data reveal that bicalutamide monotherapy provides survival benefits for untreated locally advanced disease that do not differ significantly from those of castration and maintains better physical capacity and sexual interest.
Bicalutamide (Casodex®) in the treatment of prostate cancer
- MedicineExpert review of anticancer therapy
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Nonsteroidal antiandrogens such as bicalutamide (Casodex®) offer an effective alternative to castration with potential quality-of-life benefits in men with prostate cancer.
Management of gynaecomastia in patients with prostate cancer: a systematic review.
- MedicineThe Lancet. Oncology
- 2005
Sexual Function: Quality of Life Issues in Patients with Locally Advanced Non-Metastatic Prostate Cancer
- Medicine
- 2002
Leuprorelin depot injection: patient considerations in the management of prostatic cancer
- Medicine, BiologyTherapeutics and clinical risk management
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This review emphasizes the newer, long-acting formula, leuprorelin (leuprolide acetate), especially the 6-month formula, its advantage over over shorter-acting depot products, and its potential to become a standard of care for patients eligible for androgen deprivation therapy.
Is there a role for antiandrogen monotherapy in patients with metastatic prostate cancer?
- Medicine, BiologyProstate Cancer and Prostatic Diseases
- 2001
Patients with a higher disease burden (PSA >400 ng/ml) may decide that quality of life and symptomatic benefits outweigh the slight survival disadvantage seen in clinical trials and opt for bicalutamide monotherapy as an alternative to castration.
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