Nonsteroidal anti-inflammatory drugs increase tumor necrosis factor production in the periphery but not in the central nervous system in mice and rats.

@article{Sacco1998NonsteroidalAD,
  title={Nonsteroidal anti-inflammatory drugs increase tumor necrosis factor production in the periphery but not in the central nervous system in mice and rats.},
  author={Silvano Sacco and Davide Agnello and Marcello Sottocorno and Gianluca Lozza and Angela Monopoli and Pia Villa and Pietro Ghezzi},
  journal={Journal of neurochemistry},
  year={1998},
  volume={71 5},
  pages={
          2063-70
        }
}
Nonsteroidal anti-inflammatory drugs (NSAIDs), which inhibit prostaglandin (PG) synthesis, augment production of tumor necrosis factor (TNF) in most experimental models. We investigated the effect of two NSAIDs, indomethacin and ibuprofen, on the production of TNF in the CNS induced by intracerebroventricular injection of lipopolysaccharide (LPS). Indomethacin and ibuprofen, administered intraperitoneally, augmented (three- to ninefold) the levels of TNF in serum and peripheral organs of mice… CONTINUE READING

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