Nonsteroidal anti-inflammatory drugs increase TNF production in rheumatoid synovial membrane cultures and whole blood.

Abstract

Nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit cyclooxygenase activity and hence PG production. However, the ability of NSAIDs to ameliorate pain and tenderness does not prevent disease progression in rheumatoid arthritis, a disease whose pathogenesis is linked to the presence of proinflammatory cytokines, such as TNF-alpha. To understand this… (More)
DOI: 10.4049/jimmunol.1000906

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@article{Page2010NonsteroidalAD, title={Nonsteroidal anti-inflammatory drugs increase TNF production in rheumatoid synovial membrane cultures and whole blood.}, author={Theresa H. Page and Jeremy Turner and Anthony M. Brown and Emma M. Timms and Julia J. Inglis and Fionula Mary Brennan and Brian M. J. Foxwell and Keith P. Ray and Marc Feldmann}, journal={Journal of immunology}, year={2010}, volume={185 6}, pages={3694-701} }