Nonsteroidal anti-inflammatory drugs efficiently reduce the transport and cytotoxicity of adefovir mediated by the human renal organic anion transporter 1.

@article{Mulato2000NonsteroidalAD,
  title={Nonsteroidal anti-inflammatory drugs efficiently reduce the transport and cytotoxicity of adefovir mediated by the human renal organic anion transporter 1.},
  author={Andrew S Mulato and Edmund S Ho and Tom{\'a}{\vs} Cihl{\'a}ř},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2000},
  volume={295 1},
  pages={10-5}
}
Adefovir is a nucleotide analog with anti-human immunodeficiency virus (HIV) activity that has been extensively studied in clinical trials. While on prolonged anti-HIV therapy with adefovir, some patients may develop drug-associated nephrotoxicity manifested by changes in laboratory markers of renal tubular functions that are reversible upon drug discontinuation. It has been recently shown that adefovir is efficiently transported by the human renal organic anion transporter 1 (hOAT1), a… CONTINUE READING

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Expression of the human renal organic anion transporter 1 (hOAT1) potentiates in vitro cytotoxicity of cephalosprin antibiotics

  • DC Lin, ES Ho, DB Mendel, T Cihlar
  • 39th Interscience Conference on Antimicrobial…
  • 1999
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