Nonsteroidal anti-inflammatory drugs can lower amyloidogenic Abeta42 by inhibiting Rho.

@article{Zhou2003NonsteroidalAD,
  title={Nonsteroidal anti-inflammatory drugs can lower amyloidogenic Abeta42 by inhibiting Rho.},
  author={Yan Zhou and Yuan Su and Baolin Li and Feng Liu and John W. Ryder and Xin Di Wu and P. A. Gonzalez-DeWhitt and Valentina Gelfanova and John E. S. Hale and PhilipR. A. May and Steven M Paul and Binhui Ni},
  journal={Science},
  year={2003},
  volume={302 5648},
  pages={
          1215-7
        }
}
A subset of nonsteroidal anti-inflammatory drugs (NSAIDs) has been shown to preferentially reduce the secretion of the highly amyloidogenic, 42-residue amyloid-beta peptide Abeta42. We found that Rho and its effector, Rho-associated kinase, preferentially regulated the amount of Abeta42 produced in vitro and that only those NSAIDs effective as Rho inhibitors lowered Abeta42. Administration of Y-27632, a selective Rock inhibitor, also preferentially lowered brain levels of Abeta42 in a… CONTINUE READING

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