Nonsteroidal anti-inflammatory drugs are associated with increased neuritic plaques.

  title={Nonsteroidal anti-inflammatory drugs are associated with increased neuritic plaques.},
  author={Joshua A. Sonnen and Eric B. Larson and Rod L Walker and Sebastien Haneuse and Paul K Crane and Shelly L. Gray and John C. S. Breitner and Thomas J. Montine},
  volume={75 13},
OBJECTIVES Observational and experimental studies suggest that nonsteroidal anti-inflammatory drugs (NSAIDs) may protect against Alzheimer disease (AD); however, clinical trials and other observational studies, including the Adult Changes in Thought (ACT) study, show no protection or promotion of AD. The objective of this study is to determine the relationship between common dementia-associated pathologies and mid- to late-life NSAID exposure. METHODS We examined the association of mid- to… CONTINUE READING
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