Corpus ID: 25072818

Nonsteroidal anti-inflammatory drugs (NSAID) sparing effects of glucosamine hydrochloride through N-glycosylation inhibition; strategy to rescue stomach from NSAID damage.

@article{Park2013NonsteroidalAD,
  title={Nonsteroidal anti-inflammatory drugs (NSAID) sparing effects of glucosamine hydrochloride through N-glycosylation inhibition; strategy to rescue stomach from NSAID damage.},
  author={So Hye Park and Hua Hong and Yu Mi Han and Napapan Kangwan and Sun Joong Kim and Eric H. Kim and Ki-Baik Hahm},
  journal={Journal of physiology and pharmacology : an official journal of the Polish Physiological Society},
  year={2013},
  volume={64 2},
  pages={
          157-65
        }
}
  • So Hye Park, Hua Hong, +4 authors Ki-Baik Hahm
  • Published 2013
  • Biology, Medicine
  • Journal of physiology and pharmacology : an official journal of the Polish Physiological Society
  • Gastrointestinal or cardiovascular complications limit nonsteroidal anti-inflammatory drugs (NSAID) prescription. Glucosamine hydrochloride (GS-HCl) alternatively chosen, but debates still exist in its clinical efficiency. COX-2 instability through inhibiting COX-2 N-glycosylation of GS-HCl raised the possibility of NSAID sparing effect. Study was done to determine whether combination treatment of glucosamine and NSAID contributes to gastric safety through NSAID sparing effect. IEC-6 cells were… CONTINUE READING

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