Nonsteroidal Antiinflammatory Drugs During Third Trimester and the Risk of Premature Closure of the Ductus Arteriosus: A Meta-Analysis

@article{Koren2006NonsteroidalAD,
  title={Nonsteroidal Antiinflammatory Drugs During Third Trimester and the Risk of Premature Closure of the Ductus Arteriosus: A Meta-Analysis},
  author={Gideon Koren and Ana Florescu and Adriana Moldovan Costei and Radinka Boskovic and Myla Moretti},
  journal={Annals of Pharmacotherapy},
  year={2006},
  volume={40},
  pages={824 - 829}
}
Background: Nonsteroidal antiinflammatory drugs (NSAIDs) are increasingly being used during pregnancy to treat a variety of conditions. An evaluation of the risk of premature closure of the ductus arteriosus is useful in determining the safety of NSAIDs at different stages of pregnancy. Objective: To determine whether NSAID use during the third trimester of pregnancy is associated with an increased risk of premature constriction of the ductus arteriosus. Methods: A systematic review was… 

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